The two girls were reportedly travelling in the same car, which collided with another vehicle, on a road north of Rosedale.
Police closed the road, to create a safe landing area for the RACQ LifeFlight Rescue helicopter, then drove the flight paramedic to the accident scene.
He assessed the condition of the accident patients, who were being treated by two Queensland Ambulance Service (QAS) crews.
The two girls were transported to the waiting chopper, then airlifted together, to Bundaberg Hospital, where relatives were waiting for them.
The teenagers were in a serious, but stable condition.