It is understood the vehicle was travelling along the Bruce Highway at Kybong when it veered off the road and collided with a tree.
The woman was entrapped in the vehicle for a short period before emergency services could extricate her from the wreckage.
The Sunshine Coast RACQ CareFlight Rescue helicopter was called to the scene at 2.30pm, landing in a nearby paddock within 15 minutes.
She was flown to Nambour General Hospital in a serious condition.