The crash occurred ten kilometres south of the Ettamogah Pub on the southern side of the highway.
The impact has wrapped the vehicle around it.
QAS, fire services and police are all working to free the man.
RACQ CareFlight Rescue is on standby to transfer the patient to hospital.
It was the first of two crashes within five minutes and 50 metres of each other.
A motorcycle and truck also collided.
No further details are available on the second crash.