The rescue chopper landed at a private property, south-west of Maryborough around 6pm, where the motorcycle riders had crashed.
The two injured riders were being treated at the scene by Queensland Ambulance Service (QAS) paramedics.
One male patient suffered multiple injuries, including a broken leg.
The second patient is believed to have broken his wrist.
The pair was transferred to the helicopter and airlifted together, to the Sunshine Coast University Hospital.
It was the second double airlift in less than 24 hours for the Bundaberg RACQ LifeFlight Rescue crew.
In the early hours of this morning, two teenage girls were flown to hospital, following a head-on collsion between two vehicles on a road north of Rosedale.