The crash, involving a truck and two cars, happened on the Sunshine Motorway earlier this afternoon.
RACQ LifeFlight Rescue’s critical care doctor and Queensland Ambulance Service (QAS) flight paramedic went to the scene by road.
Two patients were assessed and treated at the crash site.
The driver of one of the cars, aged in his forties, was taken by ambulance to the waiting RACQ LifeFlight Rescue helicopter, which had landed at the nearby University of Sunshine Coast campus oval.
He was suffering head and other injuries, when he was flown to the Royal Brisbane and Womens Hospital.
It was the second job for the Sunshine Coast RACQ LifeFlight Rescue helicopter today.
Earlier, the crew winched a woman, aged in her eighties, from Mount Coolum.